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Prednisolone is eliminated from the plasma with a half-life of 2—4 hours; however, the biological half-life is 18—36 hours. Prednisolone is preferred to prednisone in significant hepatic disease because prednisolone does not require hepatic activation. For systemic treatment of corticosteroid-responsive eye disorders unresponsive to topical ophthalmic treatment or for conditions usually requiring systemic treatment, such as sympathetic ophthalmia or optic neuritis. 2 to 4 mg/kg/day PO for 4 to 6 weeks, then taper over 2 to 4 weeks.
Identification cards which include the name of the patient's disease, the currently administered type and dose of corticosteroid, and the patient's physician should be carried with the patient at all times. 7.5 to 60 mg/day PO administered once daily in the morning or every other day as needed for symptom control; alternate day therapy may produce less adrenal suppression. In pediatric patients, the use of oral corticosteroids is usually limited to a few weeks until asthma control is improved and the patient can be stabilized on other, preferred treatments. Your doctor's guidelines may need to be followed while taking this medicine along with potassium-depleting agents (e.g., diuretics, amphotericin B), which are used to treat high blood pressure and fungal infections. The combined use of these medicines may increase the risk of low potassium level in the blood. Also, amphotericin B with corticosteroids may cause heart enlargement and heart failure.
Managing the side effects may also help minimize any long-term effects to some extent. Only use the measuring device provided with the medicine, when using the liquid form of prednisone. Prednisone should only be given to children when your doctor prescribes them. Never self-medicate as it can result in some serious consequences. According to the US Food and Drug Administration , the efficacy and safety of prednisone in children are backed by well-established studies.
Add CS only after exclusion of other contributory factors and consideration of other add-on treatments. Psychic derangements may appear when corticosteroids are used, ranging from euphoria, insomnia, mood swings, personality changes, and severe depression, to frank psychotic manifestations. Also, existing emotional instability or psychotic tendencies may be aggravated by corticosteroids. Aspirin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia. Growth and development of infants and children on prolonged corticosteroid therapy should be carefully observed. In patients on corticosteroid therapy subjected to unusual stress, increased dosage of rapidly acting corticosteroids before, during, and after the stressful situation is indicated.
However, sometimes an infection might not be apparent when prednisone is started, or it can develop while your child is taking the medication. It also has an effect on hormones, sometimes causing pituitary-adrenal axis suppression. Prednisone is an important medication that can treat a number of childhood illnesses, but there are important precautions to be aware of when it is used in children and adolescents.
0.14 to 2 mg/kg/day PO or 4 to 60 mg/m2/day PO per day, given in 3 to 4 divided doses. Individualize dosage to patients condition and treatment response. Infants born of mothers who have received substantial doses of corticosteroid during pregnancy should be carefully observed for signs of hypoadrenalism. While on corticosteroid therapy, patients should not be vaccinated against smallpox.
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